Selected publications from our lab:
Regulation of Magnesium Ion Transport in Escherichia coli: Insights into the Role of the 5' Upstream Region in corA Expression.
Vezina Bedard AS, Michaud A, Quenette F, Singh N, de Lemos Martins F, Wade JT, Guillier M, Lafontaine DA.
RNA Biol., In press, 2024.
Insights into the Cotranscriptional and Translational Control Mechanisms of the Escherichia coli tbpA thiamin pyrophosphate riboswitch.
Grondin JP, Geoffroy M, Simoneau-Roy M, Chauvier A, Turcotte P, St-Pierre P, Dube A, Moreau J, Masse E,Penedo JC, Lafontaine DA.
Commun. Biol., 7(1), 2024.
Cotranscriptional Folding of a 5' Stem-loop in the Escherichia coli tbpA Riboswitch at Single-nucleotide Resolution.
Hien EDM, St-Pierre P, Penedo JC, Lafontaine DA.
J. Mol. Biol., 436(22), 2024.
Structural Characterization of the Cotranscriptional Folding of the Thiamin Pyrophosphate Sensing thiC Riboswitch in Escherichia coli.
Hien EDM, Chauvier A, St-Pierre P, Lafontaine DA.
Biochemistry, 63(13), 2024.
Fluorescent riboswitch-controlled biosensors for the genome scale analysis of metabolic pathways.
Michaud A, Garneau D, Cote JP, Lafontaine DA.
Sci. Rep., 14(1), 2024.
Riboswitch and small RNAs modulate btuB translation initiation in Escherichia coli and trigger distinct mRNA regulatory mechanisms.
Bastet L, Korepanov AP, Jagodnik J, Grondin JP, Lamontagne AM, Guillier M, Lafontaine DA.
Nucleic Acids Res., 52(10), 2024.
Direct and Indirect Control of Rho-Dependent Transcription Termination by the Escherichia coli lysC Riboswitch.
Ghosh T, Jahangirnejad S, Chauvier A, Stringer AM, Korepanov AP, Cote JP, Wade JT, Lafontaine DA.
RNA, 119(20), 2024.
SHAPE-enabled fragment-based ligand discovery for RNA.
Zeller MJ, Favorov O, Li K, Nuthanakanti A, Hussein D, Michaud A, Lafontaine DA, Busan S, Serganov A, Aube J, Weeks KM.
Proc Natl Acad Sci U S A., 119(20), 2022.
Site-specific photolabile roadblocks for the study of transcription elongation in biologically complex systems.
Nadon JF, Epshtein V, Cameron E, Samatov MR, Vasenko AS, Nudler E, Lafontaine DA.
Commun. Biol., 5(1), 2022.
Monitoring RNA dynamics in native transcriptional complexes.
Chauvier A, St-Pierre P, Nadon JF, Hien E, Perez-Gonzalez C, Eschbach SH, Lamontagne AM, Penedo JC, Lafontaine DA.
Proc Natl Acad Sci U S A., 118(45), 2021.
Inactivation of the riboswitch-controlled GMP synthase GuaA in Clostridioides difficile is associated with severe growth defects and poor infectivity in a mouse model of infection.
Smith-Peter E, Lalonde Seguin D, St-Pierre E, Sekulovic O, Jeanneau S, Tremblay-Tetreault C, Lamontagne AM, Lafontaine DA, Fortier LC.
RNA Biol, 18, 2021.
A structural intermediate pre-organizes the add adenine riboswitch for ligand recognition.
St-Pierre P, Shaw E, Jacques S, Dalgarno PA, Perez-Gonzalez C, Picard-Jean F, Penedo JC, Lafontaine DA..
Nucleic Acids Res, 49(10), 2021.
Riboswitch regulation mechanisms: RNA, metabolites and regulatory proteins.
Bedard AV, Hien EDM, Lafontaine DA.
Biochim Biophys Acta Gene Regul Mech, 1863(63), 2020.
Role of a hairpin-stabilized pause in the Escherichia coli thiC riboswitch function.
Chauvier A, Nadon JF, Grondin JP, Lamontagne AM, Lafontaine DA.
RNA Biol, 16(8), 2019.
Unprecedented tunability of riboswitch structure and regulatory function by sub-millimolar variations in physiological Mg2.
McCluskey K, Boudreault J, St-Pierre P, Perez-Gonzalez C, Chauvier A, Rizzi A, Beauregard PB, Lafontaine DA, Penedo JC.
Nucleic Acids Res, 47(12), 2019.
The yeast telomerase module for telomere recruitment requires a specific RNA architecture.
Laterreur N, Lemieux B, Neumann H, Berger-Dancause JC, Lafontaine D, Wellinger RJ.
RNA, 24(8), 2018.
Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation.
Chauvier A, Picard-Jean F, Berger-Dancause JC, Bastet L, Naghdi MR, Dube A, Turcotte P, Perreault J, Lafontaine DA.
Nature Communications, 8:13892, 2017.
Cyclic di-GMP riboswitch-regulated type IV pili contribute to aggregation of Clostridium difficile.
Bordeleau E, Purcell EB, Lafontaine DA, Fortier LC, Tamayo R, Burrus V.
J Bacteriol, 197:819-32, 2015.
A new telomerase RNA element that is critical for telomere elongation.
Laterreur N, Eschbach S, Lafontaine DA, Wellinger R.
Nucleic Acids Res, 41:7713-24, 2013.
Dual-acting riboswitch control of translation initiation and mRNA decay.
Caron MP, Bastet L, Lussier A, Simoneau-Roy M, Masse E, Lafontaine DA.
Proceedings of the National Academy of Science USA, 109:E3444-53, 2012.
Molecular insights into the ligand-controlled organization of the SAM-I riboswitch.
Heppell B, Blouin S, Dussault AM, Mulhbacher J, Ennifar E, Penedo JC, Lafontaine DA.
Nature Chem Biol, 7:384-92, 2011.
Comparative study between transcriptionally- and translationally-acting adenine riboswitches reveals key differences in riboswitch regulatory mechanisms.
Lemay JF, Desnoyers G, Blouin S, Heppell B, Bastet L, St-Pierre P, Masse E, Lafontaine DA.
PLoS Genetics, 7:e1001278, 2011.
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